ENDOBIOS is on track to validate a high throughput screening (HTS) disruptive method for the discovery of new microbial-derived drug candidates against multiple neuropathies, challenging microbial cultures (starting from fungi and bacterial culture collections) in unprecedented new ways. Once validated, the intellectual property will serve as base for the discovery of new neuropathic agents that are silent in microbial genomes.
Why would microbes have molecules with an affinity to the human nervous system? Microbes served as templates for more complex forms of Life, including our nervous system. As an example, the description and classification of Transient Receptor Potential (TRP) ion channels is usually focused on those in mammals. However, in reality, TRP channel genes are found in fungal genomes as well as those of ciliates, flagellates, slime moulds, Trypanosome, Leishmania, and so on, indicating an early origin. Read more about Central Nervous System (CNS) disorders in the Scientific Awareness section.